Pizza can be both delicious and nutritious when made with heart-healthy ingredients and mindful preparation. Traditional pizzas often contain high amounts of saturated fats, refined flours, and sodium, which can negatively impact cardiovascular health. However, by choosing whole-grain or vegetable-based crusts, using fresh vegetables, lean proteins, moderate amounts of low-fat cheese, and healthy fats like extra virgin olive oil, pizza can become a satisfying meal that supports heart wellness. Incorporating antioxidant-rich toppings such as tomatoes, spinach, olives, and herbs further enhances the nutritional profile by reducing inflammation and improving cholesterol levels. Below are 11 nutritious pizza options inspired by Mediterranean flavors and wholesome ingredients that are easy to prepare and perfect for a heart-friendly diet.
1. Mediterranean Diet Margherita Pizza
This classic Margherita pizza uses a whole wheat crust topped with fresh tomatoes, basil, and slices of fresh mozzarella, drizzled with extra virgin olive oil. The use of whole grains and fresh produce provides fiber and antioxidants, while olive oil adds heart-healthy monounsaturated fats. This simple yet flavorful pizza aligns perfectly with Mediterranean diet principles. Get the recipe: Mediterranean Diet Margherita Pizza
2. Easy Mediterranean Pizza with Spinach, Olives, and Feta
Loaded with spinach, black olives, artichokes, red onion, and crumbled feta, this pizza is a vibrant vegetarian option rich in fiber, vitamins, and minerals. The combination of vegetables and feta cheese delivers antioxidants and calcium, while the olive oil-based dough provides healthy fats. It’s a quick, flavorful pizza ideal for a healthy weeknight dinner. Get the recipe: Easy Mediterranean Pizza
3. Whole Wheat Margherita Pizza with Fresh Basil
Using a whole wheat crust, this pizza is topped with sliced Roma tomatoes, fresh mozzarella, basil leaves, and a drizzle of extra virgin olive oil. The whole grains contribute fiber to support heart health, and the fresh tomatoes provide lycopene, a powerful antioxidant linked to reduced cardiovascular risk. Get the recipe: Whole Wheat Margherita Pizza
4. MediterrPizza with Artichokes, Goat Cheese, and Pine Nuts

This wholesome pizza features a homemade whole wheat dough topped with garlic, mozzarella, goat cheese, artichoke hearts, plum tomatoes, red onion, orange bell pepper, and pine nuts. The nuts add heart-healthy fats and antioxidants, while the vegetables provide fiber and vitamins, making this pizza both nourishing and delicious. Get the recipe: Mediterranean Pizza with Artichokes and Pine Nuts
5. Vegetarian Mediterranean Pizza with Feta and Olives
A colorful vegetarian pizza topped with tomato sauce, shredded mozzarella, fresh tomato slices, black and Kalamata olives, red onion, spinach, and crumbled feta cheese. This pizza is rich in antioxidants, fiber, and monounsaturated fats, supporting cardiovascular health and offering a satisfying meal. Get the recipe: Vegetarian Mediterranean Pizza
6. Heart-Healthy Pizza with Spinach, Mushrooms, and Swiss Cheese
Made with 100% whole wheat pizza dough, this pizza is topped with sautéed cremini mushrooms, baby spinach, homemade no-cook tomato sauce, and Swiss cheese, which is lower in sodium and fat than many cheeses. The mushrooms provide potassium and antioxidants, while spinach adds fiber and vitamins, making this a nutrient-dense, heart-friendly option. Get the recipe: Spinach, Mushroom & Swiss Pizza
7. Mediterranean Pizza
Featuring whole wheat dough, this pizza includes fresh baby spinach, sundried tomatoes packed in oil, crumbled feta, shredded mozzarella, and oregano. The sundried tomatoes and herbs add antioxidants, while the cheeses provide protein and calcium in moderation, making it a flavorful, heart-smart choice.
Get the recipe: Mediterranean Pizza
8. Healthy Pizza with Fresh Vegetables and Pesto Sauce
This pizza uses a whole-grain or cauliflower crust topped with pesto made from basil, garlic, pine nuts, parmesan, and olive oil, along with fresh vegetables like bell peppers, mushrooms, tomatoes, and spinach. Pesto provides monounsaturated fats and antioxidants, while the vegetables add fiber and vitamins, making this a vibrant, heart-healthy meal. Get the recipe: Healthy Pizza with Pesto and Veggies
9. Whole Wheat Pizza with Chicken, Arugula, and Balsamic Glaze
Topped with shredded chicken breast, fresh arugula, grape tomatoes, mozzarella, and a drizzle of balsamic glaze, this pizza combines lean protein with antioxidant-rich greens and tomatoes. The whole wheat crust adds fiber, and the balsamic glaze provides a tangy sweetness without added sugars.
Get the recipe: Chicken and Arugula Pizza
10. Cauliflower Crust Pizza with Vegetables and Feta
A low-carb alternative using cauliflower crust topped with tomato sauce, mozzarella, spinach, olives, and feta cheese. This pizza is rich in fiber, antioxidants, and heart-healthy fats, making it suitable for those seeking gluten-free or lower-calorie options. Get the recipe: Cauliflower Crust Mediterranean Pizza
11. Margherita Pizza with Whole Wheat Crust and Fresh Basil

A simple yet classic pizza with a whole wheat crust, fresh tomato slices, mozzarella, basil leaves, and a drizzle of olive oil. This pizza balances fiber, antioxidants, and healthy fats, supporting heart health while satisfying pizza cravings. Get the recipe: Classic Margherita Pizza
These 11 nutritious and healthy pizza options demonstrate that pizza can be a heart-friendly meal when made with wholesome ingredients like whole grains, fresh vegetables, lean proteins, and healthy fats such as olive oil. Incorporating antioxidant-rich toppings and minimizing processed ingredients helps reduce inflammation, improve cholesterol, and support overall cardiovascular wellness. Whether you prefer classic Margherita, vegetable-loaded Mediterranean styles, or protein-packed variations, these recipes offer delicious, satisfying ways to enjoy pizza while prioritizing your heart health. Experiment with these flavorful options to make pizza a nutritious part of your balanced diet.